At ILDONG Bioscience, we are committed to pioneering research in probiotics and postbiotics, exploring their diverse applications beyond gut health. One of our latest breakthroughs involves Lactobacillus johnsonii IDCC 9203 lysate and its potential role in promoting hair growth. A recently registered patent highlights its ability to enhance the proliferation of human dermal papilla cells and significantly increase β-catenin levels—an essential factor in hair regeneration.
The Science Behind β-Catenin and Hair Growth
Hair growth is a complex biological process regulated by multiple signaling pathways. Among them, the Wnt/β-catenin pathway plays a crucial role in activating hair follicle stem cells and promoting the anagen (growth) phase of the hair cycle. Higher β-catenin expression is associated with increased hair follicle activity, making it a key target for hair regeneration therapies.
Minoxidil, a well-known hair growth treatment, functions by upregulating β-catenin expression, thereby stimulating hair follicle cells. Our research suggests that Lactobacillus johnsonii IDCC 9203 lysate can achieve a similar effect, positioning it as a promising natural alternative for hair growth solutions.
Experimental Evidence: β-Catenin Enhancement with IDCC 9203 Lysate
To validate the hair growth potential of Lactobacillus johnsonii IDCC 9203 lysate, human dermal papilla cells were cultured and treated with different concentrations of the lysate (1% and 2.5%) alongside 20μM of minoxidil as a positive control. After 24 hours, total RNA was extracted, and β-catenin expression was quantified through real-time PCR analysis using the QuantStudio™ 1 Real-Time PCR System.
Key Findings:
Minoxidil treatment tripled β-catenin expression compared to the control group (p < 0.05).
Lactobacillus johnsonii IDCC 9203 lysate at 2.5% concentration significantly increased β-catenin levels by 1.2 times (p < 0.05).
These results indicate that IDCC 9203 lysate effectively enhances β-catenin expression, supporting its potential role in stimulating hair follicle activity and promoting hair growth.
A New Frontier in Probiotic-Based Hair Care
The discovery of Lactobacillus johnsonii IDCC 9203 lysate's effect on β-catenin levels opens new possibilities for microbiome-based hair growth solutions. As a natural, innovative ingredient backed by scientific validation, it has the potential to be integrated into functional cosmetics and hair care formulations.
At ILDONG Bioscience, we continue to explore novel applications of probiotics and postbiotics, leveraging our expertise in microbiome research to develop next-generation solutions. Stay tuned as we advance our research and bring cutting-edge probiotic innovations to the market.
Unlocking Hair Growth Potential: The Power of Lactobacillus johnsonii IDCC 9203 Lysate
For more insights into our research and proprietary ingredients, visit www.ildongbio.com.